
Scholarly Interest:
Functional genomics
in parasitic protozoa to identify druggable targets that are involved
in DNA metabolism and epigenetics. This work is focused on the functional
characterization of apicomplexan parasite (Cryptosporidium, Plasmodium,
Toxoplasma) DNA replication proteins and chromatin remodeling enzymes
at the molecular level, the development of high-throughput drug screens
for inhibitors of these enzymes, and validation of these proteins
as targets for anti-parasitic chemotherapy.